Dangerous equine skin condition not always genetic
A squad of researchers at Texas A&M University enjoin that a unsafe peel status affecting quarter horses tin hand the axe impact whatever breed of Equus caballus without genetic links.
Hereditary equine regional dermal asthenia (HERDA; “hyperelastosis cutis”) mainly affects quarter horses, which convey a defect inward their collagen fibers or inward the means those fibers are structurally organized inward the mid to deep dermis. In such horses, the peel over the dorsum in addition to sides of the cervix is easily torn or stretched, in addition to it frequently develops seromas in addition to hematomas (“blisters” filled amongst either serum or blood).
But the researchers flora the same status – Ehlers-Danlos syndrome – can live flora inward whatever breed without the familial association typically introduce amongst HERDA.
Genetic tests on a gelding presenting amongst the status did non uncovering the mutation described inward the PPIB gene, previously shown to live associated amongst HERDA.
Lesions on the Equus caballus exhibited either a firm, scar-like appearance or a potential infinite betwixt the superficial in addition to deep dermis. Both lesioned in addition to non-lesioned peel showed prove of edema in addition to collagen fragmentation, whereas lesions were too characterized past times hemorrhage in addition to inflammation.
Three independent laboratories, each using dissimilar methods, did non find mutations inward the PPIB gene, either at the known place of the betoken mutation or at whatever other place inward the coding sequence.
“These findings are suggestive of a diagnosis of HERDA or hyperelastosis cutis inward the absence of the well-described, putatively causative mutation inward the PPIB gene.
“We suggest that, whereas HERDA refers specifically to a familial illness caused past times a mutation inward the PPIB gene, similar symptoms may inward fact live caused past times a syndrome resulting from either inherited or spontaneous mutations inward whatever of a publish of collagen-processing genes.
“We conclude that Ehlers-Danlos syndrome live diagnosed inward horses of whatever breed amongst HERDA-like pathology without the causative mutation.”
Ehlers-Danlos Syndrome inward a Quarter Horse Gelding: Influenza A virus subtype H5N1 Case Report of PPIB-Independent Hereditary Equine Regional Dermal Asthenia; Samantha M. Steelman, PhD, Nikki D. Jackson, DVM, Eleanore Conant, PhD, Rytis Juras, PhD, Ernest G. Cothran, PhD, John F. Edwards, DVM, PhD, Bhanu P. Chowdhary, VMD.
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