HERDA a debilitating genetic skin condition
Hereditary equine regional dermal asthenia (HERDA; “hyperelastosis cutis”) is a affliction that occurs early on inwards life inwards horses, writes Stephen D. White, DVM.
Most affected horses are Quarter Horses, simply registered Paint Horses as well as Appaloosas amongst Quarter Horse lineage convey been afflicted amongst this disease.
Many of the Quarter Horses are from high-quality cutting lines. The affliction (or something really similar) has too been reported inwards a cross-bred Arabian mare, a Thoroughbred gelding, a Hanoverian foal, as well as a Haflinger horse.
The working hypothesis is that these horses convey a defect inwards their collagen fibers or inwards the means those fibers are structurally organized inwards the mid to deep dermis. Typically, these areas are over the dorsum as well as sides of the neck. The pare inwards these areas may look to live easily torn or stretched, as well as it oft develops seromas as well as hematomas (“blisters” filled amongst either serum or blood). Healing per se is commonly adequate simply oft leaves rather unsightly scars.
Diagnosis is oft based on the clinical signs alone; histologic findings are sometimes subtle, simply “clumped” or poorly organized collagen fibers below the score of the pilus follicles may live seen. Influenza A virus subtype H5N1 zone of mid to deep-dermal separation has been reported inwards 2 horses, as well as it has been introduce inwards around of the biopsy samples that the writer has seen.
“Poorly oriented” collagen fibers are sometimes seen on electron microscopy. There is no blood examination to confirm the disease.
This status is almost for sure introduce at birth; however, it is oft non noticed until close 2 years of historic menstruum when horses start beingness trained amongst tack, as well as the friction/trauma of this induces the typical lesions.
As amongst many genetic diseases, in that place is no effective handling or cure, simply around of these horses convey been maintained every bit “pasture pets.”
This affliction follows an autosomal recessive trend of inheritance; therefore, for the foal to live affected, both the sire as well as the dam must acquit the gene, as well as if they were bred again, in that place would live close a 25% direct a opportunity that the adjacent foal would too live affected.
Obviously, clinically affected horses amongst the affliction should live removed from breeding programmes.
There is directly a diagnostic examination for HERDA developed past times researchers at the University of California, Davis.
» Dangerous equine pare status non ever genetic
• This article was business office of an address past times Stephen D. White, DVM, Diplomate ACVD, on equine dermatology at the 2006 AAEP Convention. It was start published on Horsetalk.co.nz inwards May, 2007.
References as well as Footnotes
- Hardy MH, Fisher KR, Vrablic OE et al. An inherited connector tissue affliction inwards the horse. Lab Invest 1988;59:253– 262.
- White SD, Affolter V, Bannasch DL, et al. Hereditary equine regional dermal asthenia (HERDA; ‘Hyperelastosis cutis’) inwards fifty horses: clinical, histologic as well as immunohistologic findings. Vet Dermatol 2004;15:207–217.
- Solomons B. Equine cutis hyperelastica. Equine Vet J 1984;16:541–542.
- Gunson DE, Halliwell RE, Minor RR. Dermal collagen degradation as well as phagocytosis. Occurrence inwards a Equus caballus amongst hyperextensible frail skin. Arch Dermatol 1984;120:599–604.
- Witzig P, Suter M, Wild P, et al. Dermatosparaxis inwards a foal as well as a cow.a rare disease? Schweiz Arch Tierheilkd 1984; 126:589–596.
- Scott DW, Miller WH Jr. Equine dermatology. St. Louis: W.B. Saunders, 2003;640.
- Brounts SH, Rashmir-Raven AM, Black SS. Zonal dermal separation: a distinctive histopathological lesion associated amongst hyperelastosis cutis inwards a Quarter Horse. Vet Dermatol 2001;12:219–221.
- Tryon RC, White SD, Famula TR, et al. Inheritance of hereditary equine regional dermal asthenia (HERDA) inwards the American Quarter Horse. Am J Vet Res 2005;66:437– 442
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