Hendra vaccine proves effective against Nipah in monkeys
Researchers accept successfully tested inwards monkeys a vaccine against Nipah virus, a human pathogen that emerged inwards 1998 during a large outbreak of infection together with illness amid pigs together with pig farmers inwards Southeast Asia.
This latest advance builds on before function past times the scientists, who constitute that the same vaccine tin protect cats from Nipah virus together with ferrets together with horses from the closely related Hendra virus.
Both viruses accept a high fatality charge per unit of measurement inwards humans—more than 75 per centum for Nipah together with threescore per centum for Hendra.
Infections past times these viruses target the lungs together with brain, together with illness outbreaks accept occurred regularly inwards the past times decade.
Nipah outbreaks accept occurred inwards Malaysia, Singapore, People's Republic of Bangladesh together with India. Hendra outbreaks accept remained confined to Commonwealth of Australia since its emergence at that topographic point inwards horses together with humans inwards 1994. Certain fruit bats, every bit good known every bit flight foxes, spread the viruses. So far, solely Nipah is known to spread from person-to-person.
The enquiry grouping developed a vaccine based on a Hendra virus surface protein, the G glycoprotein, a known target for triggering a protective host immune response.
In this study, they used the of late developed African light-green monkey model of Nipah illness to exam 3 unlike doses of the vaccine inwards combination amongst an adjuvant. All nine vaccinated animals survived a lethal Nipah virus challenge given 42 days afterward the initial vaccination.
Dr Christopher Broder, of the Uniformed Services University of the Health Sciences, and Dr Katharine Bossart, a quondam graduate pupil of the academy straight off at Boston University, developed the vaccine.
Dr Heinz Feldmann, of Rocky Mountain Laboratories, purpose of the National Institute of Allergy together with Infectious Diseases at the National Institutes of Health, together with Dr Thomas Geisbert, of the University of Texas Medical Branch at Galveston, oversaw the enquiry inwards African light-green monkeys.
The grouping is planning additional studies to get together to a greater extent than information to include inwards an application for possible review past times the States of America Food together with Drug Administration to license the vaccine for usage inwards humans. The vaccine is inwards commercial evolution inwards Commonwealth of Australia for usage inwards horses.
K Bossart et al. Influenza A virus subtype H5N1 Hendra virus G glycoprotein subunit vaccine protects African light-green monkeys from Nipah virus challenge. Science Translational Medicine. DOI: 10.1126/scitranslmed.3004241 (2012).
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