Test developed for agent with potential for horse doping
New interrogation provides a method to discovery the performance-enhancing agent peginesatide inwards horses
Peginesatide is the showtime instance of a novel shape of compounds that mimic the effects of erythropoietin; these include an increment inwards the issue of reddish blood cells too of haemoglobin levels inwards the blood.
Both of these increment endurance and, equally a so-called erythropoiesis-stimulating agent, are banned inwards human too equine sports.
The approving of the usage of peginesatide past times the United States of America of America Food too Drug Administration to process anaemia inwards patients on dialysis increases its availability too the risk of its usage inwards illegal surgery enhancement.
A novel volume spectrometry method for detecting peginesatide inwards humans has already been developed, too right away the extension of this for the detection of peginesatide inwards Equus caballus serum is described inwards an article published inwards the European Journal of Mass Spectrometry, written past times Ines Möller, Andreas Thomas, Anke Wingender, Marc Machnik, Wilhelm Schänzer too Mario Thevis from the German linguistic communication Sport University Cologne, inwards Germany.
The interrogation is timely since the German linguistic communication Equestrian Federation lately added peginesatide to its banned marrow list.
The novel method uses electrospray ionisation liquid chromatography-tandem volume spectrometry.
According to atomic number 82 writer Mario Thevis: “The method is precise, specific too linear over a broad concentration range.
“Further, beingness simple, fast, terms effective, easily transferable to other laboratories too inwards accordance amongst the criteria for ‘identification past times chromatography too volume spectrometry’ outlined past times the Association of Official Racing Chemists, the method is suitable for routine usage inwards the Equus caballus sports drug testing arena.”
Ines Möller, Andreas Thomas, Anke Wingender, Marc Machnik, Wilhelm Schänzer too Mario Thevis, “Detection of peginesatide inwards equine serum using liquid chromatography-tandem volume spectrometry for doping command purposes”, Eur. J. Mass Spectrom. 18(4), inwards press (2012), http://dx.doi.org/10.1255/ejms.1189
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