LSU reports on horse study over pergolide approval
“La Veterinaire”, the News-Magazine of the Louisiana State University School of Veterinary Medicine, reports on the piece of work of Professor Frank Andrews, including an of import study which showed pergolide equally a suitable handling for equine Cushing’s disease.
Researchers at Lousiana State University’s School of Veterinary Medicine oftentimes partner with industry inward the search for novel treatments for animal as well as human diseases.
Dr Frank Andrews, professor of veterinary medicine as well as managing director of the Equine Health Studies Program, brings sense as well as expertise to corporate/academic partnerships to railroad train novel treatments for horses.
In a recent study funded past times Boehringer Ingelheim Vetmedica, Inc (BVIM), Dr Andrews participated inward inquiry to railroad train the drug pergolide to process 1 of the most mutual conditions of horses older than fifteen years, equine Cushing’s disease, otherwise known equally pituitary pars intermedia dysfunction (PPID).
Horses amongst PPID exhibit hirsutism (long, curly pilus coats that do non shed properly), increased H2O consumption, lethargy, muscle wasting, laminitis, as well as secondary infections, including sole abscesses, molar origin infections, as well as sinusitis.
The pituitary gland, at the base of operations of the brain, normally produces a broad array of of import hormones that regulate organ functions.
In PPID, the middle lobe of the pituitary gland (pars intermedia) becomes enlarged as well as overproduces cortisol. In salubrious horses, cortisol production is inhibited by dopamine as well as thus that unloose of the hormone is tightly controlled. Horses amongst PPID do non seem to create dopamine inward adequate levels as well as thus that cortisol unloose continues unabated without regulation.
In this sense, lack of dopamine production in PPID is analogous to the diminished dopamine availability observed inward human Parkinson’s disease; however, because a different constituent of the encephalon is involved, the resulting illness is quite different.
The clinical lawsuit undertaken past times Dr Andrews inward collaboration with researchers at Michigan State University as well as Oklahoma State University, inward a multicenter effort, demonstrated that the clinical signs of PPID tin dismiss hold upwards controlled past times direction of pergolide, which manifestly acts equally a dopaminergic agent inhibiting excessive cortical production from the pars intermedia of the pituitary gland.
Horses inward the study showed improved pilus coat, more complete as well as timely shedding, increased musculus mass, and a amend mental attitude.
In addition, at that spot was less risk of developing laminitis and infections, such equally sinusitis, pneumonia, as well as molar root abscesses.
These studies resulted in pergolide beingness accepted as the showtime Food & Drug Administration-approved drug for treatment of PPID inward horses.
Dr Andrews also assisted BVIM inward developing a website to educate clients as well as veterinarians about PPID (http://www.prascend.com).
Dr Andrews has performed many studies on the pathogenesis, treatment, as well as prevention of equine gastric ulcer syndrome (EGUS). The anatomy of the equine tummy makes it uniquely predisposed to the formation of mucosal ulcers, which leads to misfortunate performance, colic (abdominal pain), roughened pilus coat, lack of appetite, as well as weight loss, a existent occupation inward both weanling as well as performance horses.
Recently at that spot has been considerable involvement inward the utilization of plants, herbs, minerals as well as natural agents offered equally feed supplements to foreclose EGUS as well as gastric ulceration inward humans.
Using a model where he tin dismiss assess the impact of supplements on gastric mucosal integrity, Dr Andrews is currently investigating the efficacy of several feed supplements to foreclose EGUS, including an extract of Seabuckthorn berries (Hippophae rhamnoides) as well as a combination of performance minerals as well as a gut-conditioning agent. Initial studies of this latter production seem promising for the prevention of EGUS afterwards initial treatment.
To amend empathise gastrointestinal function, Dr Andrews has been using a wireless capsuled gastrointestinal monitoring organisation that measures pH, temperature, pressure, as well as transit time afterwards it is swallowed. As the capsule passes through the gastrointestinal tract, it transmits information to a monitor attached to the patient. This allows an accurate as well as non-invasive estimation of gastric emptying fourth dimension (the fourth dimension required for food to top through the stomach) as well as transit fourth dimension through the rest of the gastrointestinal tract.
Dr Andrews institute that the adult horse empties the tummy inward near 8 hours and it takes near 48 hours for cloth to traverse the entire 140 feet of a horse’s intestines. Dr Andrews believes that such a non-invasive model volition allow him to assess the impact of medications on gastrointestinal business office as well as help inward the diagnosis of diseases of the tummy as well as intestines that alter motility, such equally duodenal strictures (narrowing) as well as colic.
“By edifice relationships amongst industry, academic research institutions, such equally LSU, tin dismiss pose into practise as well as explore the feasibility of cutting-edge technology as well as innovative medicines to diagnose as well as process diseases affecting horses as well as other animals,” Dr Andrews said.
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