Eight projects get $A3m in Hendra funding
Eight projection exploring how Australia’s deadly Hendra virus affects humans volition have $A3 meg inwards funding.
The funding annunciation follows ii cases inwards Queensland inwards the concluding week, every bit the warmer regions of Commonwealth of Australia larn inwards the high-risk flavor for the disease, which is endemic inwards native fruit bats.
The virus is able to last passed to horses in addition to is in addition to then capable of existence transmitted to humans. Of 7 known cases inwards people, 4 accept proved fatal. The concluding ii victims were equine veterinarians.
Health Minister Tanya Plibersek said the enquiry aimed to pick out close a meliorate agreement of the virus, the evolution of management procedures in addition to improved patient treatments.
“The Government is committed to strengthening Australia’s biosecurity defences yesteryear funding lineament scientific enquiry that helps to protect the acre against Hendra virus.”
Three grants totalling $A1.6 meg volition examine immunological responses to exposure to the Hendra virus, creating cognition close how host organisms react to the virus.
Five grants totalling $A1.4 meg volition back upwards enquiry into possible diagnostic markers, vaccines in addition to antiviral drug targets.
Plibersek said the funding was usage of an overall $A12 meg collaborative endeavour betwixt the Commonwealth, in addition to the New South Wales in addition to Queensland governments.
The funding annunciation follows a recent urgent telephone telephone for Research yesteryear the National Health in addition to Medical Research Council. It identified areas for enquiry in addition to subjected the grant applicants to rigorous review, amongst viii of the best proposals having immediate access to funding.
“The telephone telephone for enquiry has been highly effective inwards recruiting the best enquiry proposals to increase the torso of cognition close human wellness issues related to Hendra virus,” the council’s principal executive, Professor Warwick Anderson, said.
Funding was approved for the next projects:
- Immunological responses to exposure
Research Title: Understanding pathogenicity in addition to immunity inwards an encephalitic mouse model of Hendra virus infection
Researcher: Doctor John Stambas, Deakin University
Funding amount: $562,350
Our agreement of Hendra virus infection in addition to immunity is extremely express in addition to has been hampered yesteryear a lack of appropriate beast models of illness in addition to reagents. This projection volition employ a newly established mouse model to study encephalitis, the most life-threatening manifestation of this infection. We volition usage unique, state-of-the-art infrastructure in addition to a plethora of mouse-specific reagents to investigate the mechanisms involved inwards regulating the host reply to infection.
- Can the bat immune reply to Hendra inform drug in addition to vaccine evolution inwards other species?
Researcher: Associate Professor Anthony Purcell, Monash University
Funding amount: $637,020
We volition examine why bats tin last infected amongst Hendra virus amongst no apparent symptoms, soundless the virus causes severe illness inwards other mammals including humans. We volition examine the innate immune reply towards the virus inwards the natural host (fruit bats), horses in addition to humans. In add-on to the innate immune reply nosotros volition too examine the adaptive immune reply inwards bats in addition to humans. We hope this information tin last used to pattern novel drugs or vaccines to Hendra virus.
- Identification of viral-cellular interacting factors for an in-depth agreement of the Hendra virus life wheel in addition to pathogenesis
Researcher: Associate Professor Hans Netter, Monash University
Funding amount: $368,510
Hendra virus is an emerging pathogen indigenous to fruit bats. Hendra virus is associated amongst express outbreaks amongst high mortality inwards domesticated animals in addition to humans. To advance the agreement of Hendra virus–related pathogenesis, nosotros volition perform comparative studies inwards bat in addition to human prison theatre cellphone lines to recognise differences inwards virus-host prison theatre cellphone interactions leading to a comprehensive agreement of the Hendra virus lifecycle in addition to pathogenesis.
- Vaccine options
Research Title: New Hendra virus treatments
Researcher: Associate Professor Nigel McMillan, Griffith University
Funding amount: $197,450
Hendra virus outbreaks accept larn frequent in addition to 7 human cases accept been reported, this has resulted inwards 4 deaths. Currently nosotros accept no handling options. Researchers at Griffith University in addition to the CSIRO accept developed a novel handling that attacks the virus yesteryear turning off the viral genes at the site of infection. The innovation is to care for patients before long later on infection to dull or halt the virus in addition to allow patients to recover naturally from this highly lethal disease.
- Safety assessment of an anti-Hendra virus antibody inwards humans
Researcher: Doctor Geoffrey Playford, University of Queensland
Funding amount: $400,000
Hendra virus infection inwards humans is a serious, in addition to oft fatal, disease. No cure exists for Hendra infection in addition to existing treatments are ineffective. Recently, a human monoclonal antibody has shown corking hope inwards protecting animals from developing the disease. This projection aims to perform preclinical security testing in addition to a Phase I clinical trial to found the security profile of this antibody such that it tin last used to forbid Hendra infection inwards humans exposed to the disease.
- Hendra virus vaccine
Researcher: Professor Geoffrey Pietersz, Macfarlane Burnet Institute for Medical Research in addition to Public Health
Funding amount: $189,917
Hendra virus campaign a illness transmitted from bats to horses which inwards plough infect humans in addition to other horses. There are no drugs or vaccines for Hendra virus. Since humans are infected yesteryear inhalation, a vaccine that tin generate antibody inwards the lung in addition to protect from infection volition last ideal. We accept found that a natural carbohydrate called mannan used amongst virus proteins in addition to administered via the nostrils to generate such responses. In this projection nosotros volition ready this vaccine in addition to usage it inwards a mouse model of Hendra virus infection to encounter if it tin protect the mice.
- Virus replication
Research Title: Structural studies of Hendra virus replication
Researcher: Doctor Fasseli Coulibaly, Monash University
Funding amount: $301,175
To sympathise how Hendra virus multiplies inwards infected cells, nosotros volition investigate the construction of its replicative machinery. This volition furnish the footing for rational drug pattern increasing Australia’s preparedness against the emergence of Hendra-like viruses.
Research: diagnostic markers
- Defining the usage of microRNAs inwards human Hendra virus infections
Researcher: Doctor Cameron Stewart, CSIRO Division of Livestock Industries
Funding amount: $346,064
This projection aims to improve the medical management of people infected amongst Hendra virus yesteryear defining potential therapeutic windows for handling amongst antiviral strategies. The projection involves the study of microRNAs, a cast of small-scale ribonucleic acid molecules that regulate biological processes inwards eukaryotes. We volition attain upwards one's heed the usage of microRNAs inwards the Hendra virus infection physical care for inwards humans, in addition to their application every bit diagnostic markers of Hendra virus infection.
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